Jamie (Cera) is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman -- a radical spirit named Crystal Fairy (Hoffmann) -- to come along. What is meant to be a devil-may-care journey becomes a battle of wills as Jamie finds himself locking horns with his new traveling companion. But on a remote, pristine beach at the edge of the desert, the magic brew is finally imbibed, and the true adventure begins.

Alicia arrives in South America to vacation with her cousin, Sarah. When Sarah is suddenly called away, Alicia is stuck on a remote island off Chile with three of Sarah's friends, including Brink, an American exchange student with a sadistic streak. Bewildered, frightened, and unable to sleep, Alicia's reality becomes a nightmare from which there is no waking. Ancient indigenous rites, disturbing animal behavior, and captivating hypnotic trances come together in an intense exploration into the darkest corners... when the games go too far, reality unravels with astonishing and deadly consequences.

Episodic look at the life of Cuban poet and novelist, Reinaldo Arenas (1943-1990), from his childhood...